Applied Human Geneticist Job in Cambridge, Massachusetts US
Applied Human Geneticist
Org Marketing Statement Pfizer's BioTherapeutics Research division is dedicated to discovering and developing novel and differentiated biopharmaceuticals and small molecules to meet unmet medical needs. There are four primary research units within BioTherapeutics RD: Immunology and Autoimmunity (IA) RU: Focused on providing innovative therapies to transform the lives of patients with autoimmune diseases. The unit's mission is to enable focused, accountable teams to deliver positive proof of concept data by targeting key mechanisms in adaptive immunity and cytokine biology that are deeply implicated in autoimmune disease by translational clinical research. Key disease areas are rheumatoid arthritis, psoriasis, inflammatory bowel disease and lupus. Inflammation and Remodelling (IR) RU: Focused on providing innovative therapeutic options to change the lives of patients with inflammatory diseases. The unit's mission is to empower flexible, highly leveraged teams focused on the interplay of innate immunity, tissue inflammation and post-inflammatory remodelling to translate novel targets using the best modality into differentiated POCs. Additional disease areas include COPD and liver fibrosis. Orphan and Genetic Disease (OGD) RU: Focused on making safe and effective medicines for those patients afflicted with orphan and genetic diseases, building a portfolio of biopharmaceutical programs across a broad spectrum of targets, clinical diseases, and developmental stages with a primary focus on protein trafficking as mechanism of disease etiology . Centers for Therapeutic Innovation (CTI) RU: CTI is a ground-breaking open innovation business model that aligns leading scientific and clinical experts from leading Academic Medical Centers with Pfizer's world-class scientists, drug development capabilities and breadth of resources to speed the translation of innovative science into medicines for patients. There are currently centers established in San Francisco and Boston. Job Focus Responsible for providing human genetics leadership and expertise to BioTx Research Units via internal resource and external collaborations to support target selection, validation, patient stratification and evaluation of drug response, and to support the precision medicine strategy within BioTx. Responsibilities Contributes to genetics strategy in BioTx RUs and is responsible for implementation of endorsed genetics strategy Responsible for scientific quality and experimental design and interpretation of genetic projects run in within BioTx Clinical Responsible for the delivery and documentation of genetics projects Provision of expertise and advice to the RUs on the application of genetics to target selection and patient stratification Provides genetics expertise to support review committee and major decision points in the drug-development process ( PRISM, scientific review committees) Responsible for ensuring high-quality genetic data is incorporated into exploratory-research programs. Responsible for establishing and maintaining external collaborations to specified timelines and milestones Manage, support and promote relationships with the external community that can add value to target selection at Pfizer and enable collaborative use of Pfizer patient samples. Contribute effectively to the BioTx strategy for Precision Medicine Promote genetic epidemiology and population genetics both internally and externally Works with other members of Quantitative Clinical Sciences (statistics, clinical pharmacology) to ensure quantification of findings Works collaboratively with other human geneticists in Pfizer at both a scientific and infrastructure level Qualifications The successful candidate will have the following: Undergraduate degree in genetics or related subject PhD in Genetics Track record of innovative research in genetics of complex traits (first author publications) Evidence of scientific leadership role with responsibility for research project delivery. Successful track record of effectively working in multi- disciplinary teams (middle author publications) Evidence of collaborative research at a national level Advanced knowledge and understanding of DNA manipulation, genotyping and sequencing technologies. Strong knowledge and understanding of genetic statistics analytical methods. Good working knowledge of epidemiology and population genetics. Identifies, proposes and develops new technology and methodology concepts Ideally, the candidate would also have the following: Post-doctoral studies in genetics of complex traits Experience of applying genetics to across a range of phenotypes. Previous experience of the application of genetics to drug discovery Proven track record of leading and delivering in multiple programmes in parallel. Evidence of broader impact in scientific community externally through e.g. steering committee, conference organising committee editorial board memberships. Expertise in next generation sequencing technologies Equal Employment Opportunity Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as employment eligibility verification requirements of the Immigration and Nationality Act. All applicants must have authorization to work for Pfizer in the U.S. In certain circumstances it may be advantageous to Pfizer to support the application(s) for temporary visa classification and/or sponsor applications for permanent residence so that a foreign national colleague can accept or remain in a work assignment in the U. S. For certain classes of temporary visas, the resulting work authorization may be specific to Pfizer and the specific job and/or work site. Pfizer may at its business discretion decide to or refrain from obtaining, maintaining and/or extending the temporary visa status and/or sponsoring a colleague for permanent residency and /or employment eligibility, considering factors such as availability of qualified U.S. workers and the colleague's long-term prospects for securing lawful permanent residence, among other reasons. Employment applicants requiring immigration sponsorship must disclose, when initial application for employment is made, whether or not they are legally authorized to work for Pfizer in the U.S. and, if so, whether that authorization permits them to work in the job they seek. In no case should Pfizer's support of a colleague's temporary visa application or sponsorship of a colleague for permanent residence be construed to guarantee success of that application or amend or otherwise invalidate the "at-will" employment relationship between the colleague and Pfizer. *This job post was placed on PharmaDiversity Job Board with permission of this employer. If viewing this post anywhere else, the "apply" click should lead you to PharmaDiversity Job Board for authentic job post view with direct employer application. For application attention if web source is requested please use "PharmaDiversity" or "PharmaDiversity Job Board". Pfizer prefers that you apply to this job directly on their site