In Vivo Pharmacology Team Leader, Oncology Research Job in La Jolla, California US
In Vivo Pharmacology Team Leader, Oncology Research
Org Marketing Statement Pfizer Inc: Working together for a healthier world Founded in 1849, Pfizer is the world's premier biopharmaceutical company taking new approaches to better health. We discover, develop, manufacture and deliver quality, safe and effective prescription medicines to treat and help prevent disease for both people and animals. We also partner with healthcare providers, governments and local communities around the world to expand access to our medicines and to provide better quality health care and health system support. At Pfizer, colleagues in more than 90 countries work every day to help people stay happier and healthier longer and to reduce the human and economic burden of disease worldwide. Role Description To lead a team of in vivo pharmacologists developing and implementing disease models for the mechanistic characterization and evaluation of novel anticancer therapeutics. This team will provide a critical role in the drug discovery and development process to ensure delivery of high quality in vivo data that enables drug discovery programs in the Tumor Cell Biology and Precision Medicine groups in La Jolla as well as load share in vivo studies with Pearl River discovery groups. The team leader will provide senior in vivo pharmacology expertise to the ORU and contribute to the strategic direction of the in vivo pharmacology discipline across sites and work to continuously drive improvements in operational practices that deliver solid ROI. Responsibilities "Key efforts for this leader will be to 1) oversee development and use of mouse models of cancer including patient derived xenograft models, GEMMs, and orthotopic models to evaluate novel anticancer therapeutics, 2) manage internal and external (academic and contract research organizations) resources to deliver quality data in an efficient and cost-effective manner with a strong sense of customer service. This will require proactive identification of processes and systems for continuous improvement as well as development of key partnerships with partner lines (Comparative Medicine, DSRD, PDM etc,) and judicious contracting with academic or contract research organizations. 3) mentor senior scientific staff to design and execute in vivo studies to answer key biological questions in support of project teams. 4) Chair a multi-disciplinary in vivo committee that will evaluate and approve all in vivo study design and ensure appropriate resources for executing these studies. 5) actively collaborate with in vivo lead in Pearl River to load-share across sites and design and implement standardized processes for study execution, data collection and reporting for studies performed internally and at external service providers. 6) ensure efficient management and delivery of cell bank and automated cell production (SelectT system) for the ORU in La Jolla. Qualifications Training Education Preferred: "PhD in a relevant biological scientific discipline with a focus on in vivo cancer research and 10 years experience Prior Experience Preferred "Relevant extensive experience in a cancer RD laboratory environment with pharmaceutical industry experience preferred. "Advanced training in contemporary scientific discipline with emphasis on cancer research. "Strong understanding of key components and process of drug discovery, applied pharmacology, and drug development. "Strong working knowledge of oncology disease processes, disease models, and current clinical treatments. "Experience managing of a team of research scientists required. "Experience in managing a broad scientific program utilizing relevant mouse tumor models (orthotopic, GEMMs, PDX) and applied technologies enabling in vivo analyses. "Experience and working knowledge in concepts including but not limited to genetic engineering, stable gene expression/knockdown platforms, cell and tumor biology, molecular profiling methodologies, histology/immunohostochemistry,FACS, in vivo imaging, etc. "Strong communication skills and ability to work effectively across multiple multidisciplinary teams. Equal Employment Opportunity Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as employment eligibility verification requirements of the Immigration and Nationality Act. All applicants must have authorization to work for Pfizer in the U.S. In certain circumstances it may be advantageous to Pfizer to support the application(s) for temporary visa classification and/or sponsor applications for permanent residence so that a foreign national colleague can accept or remain in a work assignment in the U. S. For certain classes of temporary visas, the resulting work authorization may be specific to Pfizer and the specific job and/or work site. Pfizer may at its business discretion decide to or refrain from obtaining, maintaining and/or extending the temporary visa status and/or sponsoring a colleague for permanent residency and /or employment eligibility, considering factors such as availability of qualified U.S. workers and the colleague's long-term prospects for securing lawful permanent residence, among other reasons. Employment applicants requiring immigration sponsorship must disclose, when initial application for employment is made, whether or not they are legally authorized to work for Pfizer in the U.S. and, if so, whether that authorization permits them to work in the job they seek. In no case should Pfizer's support of a colleague's temporary visa application or sponsorship of a colleague for permanent residence be construed to guarantee success of that application or amend or otherwise invalidate the "at-will" employment relationship between the colleague and Pfizer. *This job post was placed on PharmaDiversity Job Board with permission of this employer. If viewing this post anywhere else, the "apply" click should lead you to PharmaDiversity Job Board for authentic job post view with direct employer application. For application attention if web source is requested please use "PharmaDiversity" or "PharmaDiversity Job Board". Pfizer prefers that you apply to this job directly on their site