Scientific Assoc/Scientist, Microbiology-Antibacterial Lead Discovery Job in Emeryville 94608, California US
About Novartis Institute for Biomedical Research:
At Novartis Institutes for BioMedical Research (NIBR), the global research organization of Novartis, we are committed to discovering innovative medicines to cure disease and improve human health. We aim to hire the best trained scientists from academia, biotechnology and pharmaceuticals and we cultivate an environment for drug discovery science where innovation is rewarded. It is ultimately the talent of the individuals we recruit that determines our success and our state-of-the-art technologies and resources that enable individuals to realize this success.
NIBR conducts research globally with sites in Emeryville, California; Cambridge, MA; East Hanover, NJ; Basel, Switzerland; Horsham, UK; and Shanghai, China. Our Emeryville location focuses on drug discovery and early development for Infectious Disease and Oncology Disease Areas and is actively recruiting for a variety of positions across disciplines such as Bacteriology, Virology, Oncology, Chemistry, and other areas that support our scientific discovery.
About the Infectious Diseases Area
The Infectious Diseases Area (IDA) seeks to discover and develop treatments to address unmet medical needs in the management and cure of bacterial and viral infections. The Virology group currently focuses on infections caused by hepatitis C virus, influenza virus, respiratory syncytial virus, human cytomegalovirus and other viruses of the immunocompromised host. The Antibacterials group investigates novel therapies for multi-resistant bacterial infections caused by Gram negative and positive pathogens.
NIBR is currently expanding Infectious Diseases research in Emeryville, California at the heart of Northern California’s thriving biomedical community. With the leadership of Don Ganem, M.D., one of the world’s leading virologists, our new ID team will focus on identifying and exploiting novel molecular mechanisms for the interruption of pathogen replication and viability. In addition, we hope to break new ground in the search for novel viruses that might contribute to other human diseases, including tumors and autoimmune disorders. Our new ID headquarters in Emeryville will be fueled by a culture that combines the best of academia and biotech with the backing of a global organization - Novartis.
About the ID Lead Discovery Group:
The ID Lead Discovery group in Emeryville is part of the multidisciplinary effort aimed at the discovery of small molecule drugs for the treatment of patients with infectious diseases. In particular, we develop and run microbial phenotypic and target-based assays to identify and characterize chemical scaffolds and natural product extracts to support NCE projects aimed at developing novel agents for antibacterial therapy.
About Novartis Institute for Biomedical Research:
At Novartis Institutes for BioMedical Research (NIBR), the global research organization of Novartis, we are committed to discovering innovative medicines to cure disease and improve human health. We aim to hire the best trained scientists from academia, biotechnology and pharmaceuticals and we cultivate an environment for drug discovery science where innovation is rewarded. It is ultimately the talent of the individuals we recruit that determines our success and our state-of-the-art technologies and resources that enable individuals to realize this success.
NIBR conducts research globally with sites in Emeryville, California; Cambridge, MA; East Hanover, NJ; Basel, Switzerland; Horsham, UK; and Shanghai, China. Our Emeryville location focuses on drug discovery and early development for Infectious Disease and Oncology Disease Areas and is actively recruiting for a variety of positions across disciplines such as Bacteriology, Virology, Oncology, Chemistry, and other areas that support our scientific discovery.
About the Infectious Diseases Area
The Infectious Diseases Area (IDA) seeks to discover and develop treatments to address unmet medical needs in the management and cure of bacterial and viral infections. The Virology group currently focuses on infections caused by hepatitis C virus, influenza virus, respiratory syncytial virus, human cytomegalovirus and other viruses of the immunocompromised host. The Antibacterials group investigates novel therapies for multi-resistant bacterial infections caused by Gram negative and positive pathogens.
NIBR is currently expanding Infectious Diseases research in Emeryville, California at the heart of Northern California’s thriving biomedical community. With the leadership of Don Ganem, M.D., one of the world’s leading virologists, our new ID team will focus on identifying and exploiting novel molecular mechanisms for the interruption of pathogen replication and viability. In addition, we hope to break new ground in the search for novel viruses that might contribute to other human diseases, including tumors and autoimmune disorders. Our new ID headquarters in Emeryville will be fueled by a culture that combines the best of academia and biotech with the backing of a global organization - Novartis.
About the ID Lead Discovery Group:
The ID Lead Discovery group in Emeryville is part of the multidisciplinary effort aimed at the discovery of small molecule drugs for the treatment of patients with infectious diseases. In particular, we develop and run microbial phenotypic and target-based assays to identify and characterize chemical scaffolds and natural product extracts to support NCE projects aimed at developing novel agents for antibacterial therapy.
About the position:
We are seeking a multifaceted and driven individual with a strong scientific background and relevant expertise in the molecular discovery and characterization of natural product and small molecule inhibitors/activators of their targets. The successful candidate will have demonstrated competency in various microbial phenotypic and target-based assay technologies as part of the lead discovery and optimization process. This will entail using these assays to drive decision making activities to support programs. The selected candidate will effectively communicate results to the team
•B.S. or M.S. in microbiology, biochemistry or related discipline, with at least 3-5 years experience in a pharmaceutical or biotechnology drug discovery environment
•Demonstrated knowledge concerning procedures for growth, maintenance and safety procedures with diverse microbial organisms
•Demonstrated ability to conduct routine and specialized microbial phenotypic and target-based assays
•Experience with natural product extracts, compound screening formats, laboratory instrumentation and automation, data analysis and management, and a sound knowledge of the drug discovery process
•Skilled in small molecule assay development, lead discovery, and lead optimization
•Ability to independently design experiments and generate, analyze, and present data
•Familiarity with compound handling and the identification and implementation of new technologies that will improve the quality of lead compounds
•Strong written and verbal communication skills
•Able to work independently in a fast-paced environment
•Qualified candidates will have a commitment to scientific excellence, an appreciation for multidisciplinary technology integration, and an ability to troubleshoot and solve problems.
