Scientist, Medicinal Chemistry Job in Rockville 20852, Maryland US
Roles and Responsibilities
The Scientist, Medicinal Chemistry, will:
· Initiate, direct, and execute all OMML pre-clinical scientific research and/or development strategies in an oncology field
· Investigate the feasibility of applying a wide variety of scientific principles and concepts to potential inventions, products and problems
· Plan and execute laboratory research
· Maintain knowledge of state-of-the-art principles and theories
· Make major contributions to scientific literature and conferences
· Interface with various departments and serve as internal consultant
· Act as spokesperson on corporate research and development and advise top management
· Participate in development of patent applications
When involved in an anti-cancer drug discovery project, the Scientist, Medicinal Chemistry,
· Contribute to the development and enablement of a coherent synthesis strategy for oncology drug discovery project(s)
· Understand the goal and strategy of the project and, as part of a synthesis team, positively and proactively influence and reduce to practice through the development of innovative and practical chemistry
· Design, synthesis, purification and characterization of biologically-active organic small molecules as development candidate for the drug discovery programs
· Develop and enable versatile and modular synthetic routes compatible with rapid analog synthesis. Validation of routes through reduction to practice
· Develop scalable routes of preclinical drug candidates
· Maintain a detailed scientific notebook, analytical data and other scientific information
· Prepare reports and write up experimental to support patent filing
· Present data and progress internally and externally when necessary
· Maintain a clean and safe laboratory environment; perform routine maintenance on laboratory instruments such as HPLC and vacuum pumps
· Publish and present research internally and externally to Otsuka
· Take personal responsibility for individual and co-worker safety and strictly adhere to all safety procedures and policies
· Build effective partnerships with other lines, in particular analytical, technology, pharmaceutical sciences and process chemistry groups in Otsuka Japan.
Knowledge, Skills, Competencies, Education, and Experience Required:
· Ph.D. in a scientific discipline, and a minimum of 5+ years of demonstrated experience in the pharmaceutical industry
· Expertise in synthetic organic chemistry methodologies, transformations and mechanisms
· Strong knowledge of techniques related to purification and characterization of organic compounds
· Excellent written and oral communication skills; enthusiasm, self-motivation, strong interpersonal skill, able to interact effectively within a multidisciplinary team
Preferred:
· 1-2 years of relevant post-doctoral experience is preferred
· Practical experience of Structure or Ligand Based Drug Design and in silico screening with operating modeling soft.
· Previous experience in mentoring and development of junior scientists or students is a plus.
Apply Online at:
https://2xrecruit.kenexa.com/kr/cc/jsp/public/EmailJobDetail.jsf?npi=592BD0535B5F57261EE563929442C841rand=A63711ED680B8ACF067665677AC7AEDA
Company Description:
Otsuka Pharmaceutical Development and Commercialization, Inc. (OPDC) is involved in conducting all phases of clinical research and development of innovative healthcare products to address unmet medical needs. OPDC is well established in the scientific community as a globally focused organization that plays a leadership role in the research and development of Otsuka's ethical healthcare products. The Company is dedicated to the improvement of the quality of human life and health of its patients around the world with a strong commitment to research and development in the areas of cardiovascular, respiratory, renal and neuroscience systems, and to treat cancer and ophthalmic disorders.