Sr Research Chemical Engineer- siRNA delivery Job in Point, Pennsylvania US
Sr Research Chemical Engineer- siRNA delivery
Advance siRNA delivery vehicle formulation science to enhance potency, tolerability, stability, and robustness. Apply innovative thinking and technical depth to independently plan, conduct, and interpret laboratory experiments focused on formulation design and assembly process development. Support multiple delivery vehicle platforms, with particular emphasis on lipid-based systems, including incorporation of targeting ligands. Assure timely preparation and successful delivery of formulated materials and associated documentation for critical studies. This position offers the opportunity to work with a talented, diverse team of scientists, and develop one's career in an emerging and exciting area of drug delivery. Specific responsibilities: Develops robust, scalable, and stable parenteral lipid nanoparticle formulations and manufacturing processes to optimize potency and tolerability. Supervises manufacture and ensures on-time delivery of materials to partner groups to support critical studies. Authors and executes production records, standard operating procedures (SOPs), and other GLP/GMP records in support of pre-clinical and clinical studies. May support preparation of regulatory documentation. Develops innovative solutions to problems in frozen liquid and lyophilized liposomal formulations. Leads or participates in troubleshooting and technical investigations, as required Ensures clear communication of study plans, key data, analyses, and recommendations to team, program leads, partner groups, and management. Provides technical guidance and mentorship to junior staff Assures compliance with established policies/procedures of the Division and Corporation and complies with all applicable governmental regulations (GMP, etc.), both domestic and foreign Maintains a laboratory notebook in compliance with company policy Actively promotes a culture of safety Analyzes and optimizes systems and workflows to promote operational excellence and efficiency gains Ensures general laboratory upkeep and maintenance